- JD Pardo as Ezekiel 'EZ' Reyes
- Clayton Cardenas as Angel Reyes
- Sarah Bolger as Emily Thomas
- Michael Irby as Obispo 'Bishop' Losa
- Carla Baratta as Adelita
- Richard Cabral as Johnny 'Coco' Cruz
- Raoul Max Trujillo as Che 'Taza' Romero
- Antonio Jaramillo as Michael 'Riz' Ariza
- Danny Pino as Miguel Galindo
- Edward James Olmos as Felipe Reyes
Special Guest Star
- "Serpiente" is Spanish for "Snake", or "Serpent", and "Chikchan" is Yucatec Mayan for one of the 20-day names in the Tzolkin calendar meaning "celestial serpent".
- Snakes, with the ability to shed their skin, symbolize transformation. While some snakes are completely harmless, others carry the ability to inflict death.